{"id":4955,"date":"2022-04-01T16:04:53","date_gmt":"2022-04-01T14:04:53","guid":{"rendered":"https:\/\/www.ichthyol.de\/raw-materials-for-corporate-customers\/ichthammol\/"},"modified":"2023-04-24T09:39:32","modified_gmt":"2023-04-24T07:39:32","slug":"ichthammol","status":"publish","type":"page","link":"https:\/\/www.ichthyol.de\/en\/raw-materials-for-corporate-customers\/ichthammol\/","title":{"rendered":"Ichthammol<sup>\u00ae<\/sup>"},"content":{"rendered":"<section class=\"l-section wpb_row us_custom_5fb9c346 en_opener en_opener_lp height_auto width_full with_slider\" id=\"introduction\"><div class=\"l-section-slider\"><div class=\"w-slider style_none fit_cover nav_none count_1\"><div class=\"w-slider-h\" aria-hidden=\"true\"><div class=\"royalSlider\"><div class=\"rsContent\"><a class=\"rsImg\" data-rsw=\"1600\" data-rsh=\"1200\" href=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/01_Ichthammol-from-a-brown-bottle_bearbeitet.jpg\"><span data-alt=\"\"><\/span><\/a><\/div><\/div><img decoding=\"async\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/01_Ichthammol-from-a-brown-bottle_bearbeitet.jpg\" width=\"1600\" height=\"1200\" loading=\"lazy\" alt=\"\" title=\"\"><\/div><div class=\"w-slider-json\" onclick='return {&quot;autoScaleSlider&quot;:true,&quot;addActiveClass&quot;:true,&quot;loop&quot;:true,&quot;fadeInLoadedSlide&quot;:false,&quot;slidesSpacing&quot;:0,&quot;imageScalePadding&quot;:0,&quot;numImagesToPreload&quot;:2,&quot;arrowsNav&quot;:false,&quot;arrowsNavAutoHide&quot;:false,&quot;transitionType&quot;:&quot;move&quot;,&quot;transitionSpeed&quot;:0,&quot;block&quot;:{&quot;moveEffect&quot;:&quot;none&quot;,&quot;speed&quot;:300},&quot;thumbs&quot;:{&quot;fitInViewport&quot;:false,&quot;firstMargin&quot;:false,&quot;spacing&quot;:4},&quot;controlNavigation&quot;:&quot;none&quot;,&quot;autoScaleSliderWidth&quot;:1600,&quot;autoScaleSliderHeight&quot;:1200}'><\/div><\/div><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default\"><div class=\"vc_col-sm-12 vc_col-lg-8 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container en_opener_img\"><div class=\"vc_column-inner us_custom_9a841f71\"><div class=\"wpb_wrapper\"><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-4 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container en_opener_text\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row us_custom_ea92c9f7 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Ichthammol\u00ae&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p style=\"text-align: center;\"><strong>Ichthammol\u00ae<\/strong>, the <strong>ammonium salt of dark sulfonated shale oil<\/strong>, has been successfully used as an active ingredient of natural origin in the treatment of skin disorders <strong>for more than 100 years<\/strong>. The following pages will convince you of the documented quality and proven efficacy profile of this <strong>well-tolerated substance<\/strong>.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_c70c97eb en_overflow_hide height_large\" id=\"quality\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default reversed stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;A guarantee for good quality&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>In human and veterinary medicine, <strong>Ichthammol\u00ae<\/strong> is one of the few exceptions of <strong>well-documented active ingredients of natural origin<\/strong>. The dark sulfonated shale oil is manufactured by \u00d6STERREICHISCHE ICHTHYOL Gesellschaft m.b.H. &amp; Co. KG in Reith bei Seefeld, Austria in accordance with the requirements of different pharmacopoeias (<strong>Ph.Eur., USP<\/strong>). These requirements involve manufacture of <strong>Ichthammol\u00ae<\/strong> in constantly good quality in compliance with guidelines of good manufacturing practice (<strong>GMP<\/strong>) under consideration of general criteria (e.g. residual solvents) as well as the individual specifications of the monograph.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_1\" target=\"_blank\" rel=\"nofollow\" href=\"\/wp-content\/uploads\/2022\/09\/GMP-ICHTHAMMOL.pdf\"><span class=\"w-btn-label\">Download (PDF)<\/span><\/a><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The Ichthyol-Gesellschaft offers the original active ingredient as GMP-certified Ichthammol\u00ae in the qualities <strong>Ph.Eur., BP and USP<\/strong>, each with complete <strong>certificates of analysis<\/strong>.<\/p>\n<p>A <strong>Certificate of Suitability (CEP)<\/strong> is available for the <strong>Ph.Eur. grade<\/strong> under registration number R1-CEP 2001-274-Rev 02.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_1\" target=\"_blank\" rel=\"nofollow\" href=\"\/wp-content\/uploads\/2022\/09\/CEP-ICHTHAMMOL.pdf\"><span class=\"w-btn-label\">Download (PDF)<\/span><\/a><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs accordion toggle_style_1 has_scrolling remove_indents\" style=\"--sections-title-size:inherit;--sections-gap:0.5rem;\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"wc09\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-wc09\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Designations, key figures and definitions<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-wc09\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Ichthammol\u00ae Ph.Eur.<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>CEP<\/td>\n<td>R1-CEP 2001-274-Rev 02<\/td>\n<\/tr>\n<tr>\n<td>Synonyme<\/td>\n<td>Ammoniumbituminosulfonat<br \/>\nIchthammolum<\/td>\n<\/tr>\n<tr>\n<td>CAS#<\/td>\n<td>8029-68-3<\/td>\n<\/tr>\n<tr>\n<td>EC#<\/td>\n<td>232-439-0<\/td>\n<\/tr>\n<tr>\n<td>CAS and ECHA<br \/>\nDefinition:<\/td>\n<td>A complex product obtained by the sulfonation and ammoniation of the distillation product from bituminous schists. It may contain saturated and unsaturated hydrocarbons, nitrogen bases and thiophene derivatives.<\/td>\n<\/tr>\n<tr>\n<td>Ph.Eur. (EP)<br \/>\nDefinition:<\/td>\n<td>Ichthammol is obtained by distillation from certain bituminous schists, sulfonation of the distillate and neutralisation of the product with ammonia.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/04\/Berg_01-768x1024.jpeg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/04\/Berg_01-768x1024.jpeg 768w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/04\/Berg_01-225x300.jpeg 225w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/04\/Berg_01.jpeg 1920w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" title=\"\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_5fb9c346 en_overflow_hide height_large\" id=\"manufacture\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Fish-fossil-from-Seefeld-Paralepidotus-ornatus-1024x768.jpeg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Fish-fossil-from-Seefeld-Paralepidotus-ornatus-1024x768.jpeg 1024w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Fish-fossil-from-Seefeld-Paralepidotus-ornatus-300x225.jpeg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" title=\"\"><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Manufacture from natural origin&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The starting material for the production of <strong>Ichthammol\u00ae<\/strong> is a <strong>sulfur-rich (bituminous) sedimentary rock (schist)<\/strong> from the Mesozoic era. Kerogen is the organic material of this limestone, formed from <strong>algae and phytoplankton of marine origin<\/strong>, as it appears today after millions of years of geological processes of sedimentation and metamorphism: a rigid network of high-molecular organic compounds with a comparatively high hydrogen-carbon ratio.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs accordion toggle_style_1 has_scrolling remove_indents\" style=\"--sections-title-size:inherit;--sections-gap:0.5rem;\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"t5a0\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-t5a0\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Read more<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-t5a0\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Sulfur-rich deposits, such as those needed for the production of <strong>Ichthammol\u00ae<\/strong> according to pharmacopoeia specifications, are mostly hidden inaccessibly in the <strong>inside the Alps and the French Jura<\/strong> (calcaires bitumineux d&#8217;Orbagnoux) and have to be mined underground in a complicated <strong>chamber mining operation<\/strong>.<\/p>\n<\/div><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mine-1024x768.jpeg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mine-1024x768.jpeg 1024w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mine-300x225.jpeg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" title=\"\"><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Mining of the rock<\/strong> is followed above ground <strong>by gentle dry distillation<\/strong> in the absence of air to produce shale oil (pharma).<\/p>\n<p>The <strong>highly sulfuric shale oil<\/strong> (with approx. <strong>15% sulfur<\/strong> in organically combined form) is refined under GMP conditions in Reith near Seefeld, Austria, and further processed into <strong>Ichthammol\u00ae<\/strong>. The <strong>GMP system<\/strong> ensures that <strong>Ichthammol\u00ae<\/strong> is produced reproducibly at the site to the required pharmacopoeia quality.<\/p>\n<p>The substance, which results from the manufacturing process as a <strong>viscous, blackish-brown liquid<\/strong>, is a mixture of polar compounds, the majority of which consist of <strong>sulfonated thiophene derivatives<\/strong>. The pharmacopoeial requirements relate, among other things, to the content of <strong>organically bound sulfur<\/strong>, which is considered to be of <strong>particular therapeutic value<\/strong>. The dark sulfonated shale oil made in Austria is unique with a <strong>sulfur content of up to 20\u00a0%<\/strong> (based on the dry substance) and cannot be compared with qualities of other origin.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Please contact us for further information on the use of Ichthammol\u00ae.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_1\" href=\"\/en\/raw-materials-for-corporate-customers\/contact\/\"><span class=\"w-btn-label\">Contact<\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_c70c97eb en_overflow_hide height_large\" id=\"uniqueness\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default reversed stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;The uniqueness of Ichthammol&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The uniqueness of <strong>Ichthammol\u00ae<\/strong> from Reith bei Seefeld is proven by <strong>physico-chemical analysis<\/strong>. With the help of <strong>chromatographic methods (HPLC)<\/strong>, unambiguous information about the origin of a given sample material can be obtained even from finished products.<\/p>\n<p>In this way, it is also possible to unambiguously detect <strong>imitations<\/strong> of <strong>Ichthammol\u00ae<\/strong> that are distributed as <strong>counterfeit drugs<\/strong>. For example, in the <strong>absence of suitable shale deposits<\/strong>, sulfur is <strong>artificially<\/strong> <strong>introduced into vegetable oils<\/strong> (soybean oil) and these &#8220;sulfurized&#8221; vegetable oils are offered under the name Ichthammol after sulfonation.<\/p>\n<p>Since the syllable <strong>&#8220;Ichth&#8221;<\/strong> refers to the <strong>fossil deposits of fish (Greek &#8220;Ichthys&#8221;)<\/strong> in the source rock for the production of <strong>Ichthammol\u00ae<\/strong>, vegetable oil derivatives offered under the same name are completely misleading.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs accordion toggle_style_1 has_scrolling remove_indents\" style=\"--sections-title-size:inherit;--sections-gap:0.5rem;\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"n53a\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-n53a\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Read more<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-n53a\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The conformity with the basic <strong>definition of the active ingredient<\/strong> is indispensable for a pharmacopoeia-compliant <strong>Ichthammol\u00ae<\/strong>. For <strong>Ichthammol\u00ae<\/strong>, manufacture from certain <strong>bituminous schists<\/strong> as starting material is mandatory. Materials deviating from these criteria (e.g. from vegetable oils) do not fall within the definition of <strong>Ichthammol\u00ae<\/strong> and are therefore to be regarded as drug counterfeits in the legal areas of the pharmacopoeias concerned.<\/p>\n<p>The <strong>anti-inflammatory, anti-bacterial and anti-mycotic actions<\/strong> of <strong>Ichthammol\u00ae<\/strong> offer a <strong>broad spectrum of efficacy<\/strong> and constitute the basis for a successful application of this active ingredient in treatment of <strong>different skin disorders<\/strong> with and without microbial background.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image has_ratio align_none\"><div class=\"w-image-h\"><div style=\"padding-bottom:133.3333%\"><\/div><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/04\/Ichtyol_023_Ausschnitt-1024x576.jpeg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" title=\"\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_5fb9c346 en_overflow_hide height_large\" id=\"application\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Application&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"w-separator size_medium\"><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Ichthammol\u00ae<\/strong> is suitable as an active ingredient for the <strong>topical treatment of inflammatory skin diseases<\/strong>. Standard formulations can be found in national formulations (in Germany, for example, the NRF) or in the United States Pharmacopoeia (USP).<\/p>\n<\/div><\/div><div class=\"wpb_text_column en_b2b_tabelle\"><div class=\"wpb_wrapper\"><table>\n<tbody>\n<tr>\n<th><em>Ichthammol\u00ae Ointment 10\u00a0% USP<\/em><\/th>\n<th><em>Concentration<\/em><\/th>\n<\/tr>\n<tr>\n<td><em>Ichthammol\u00ae<\/em><\/td>\n<td><em>10\u00a0%<\/em><\/td>\n<\/tr>\n<tr>\n<td><em>Lanolin (wool wax)<\/em><\/td>\n<td><em>10\u00a0%<\/em><\/td>\n<\/tr>\n<tr>\n<td><em>Petrolatum (Vaseline)<\/em><\/td>\n<td><em>80\u00a0%<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>Ichthammol\u00ae ishould be completely incorporated into lanolin and then combined with petrolatum.<\/em><\/p>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The benefit of the <strong>well tolerated<\/strong> active ingredient <strong>Ichthammol\u00ae<\/strong> consists in the fact that the effects of <strong>several principals of action<\/strong> are interconnected. Considering for example a skin disease caused by <strong>bacterial invasion or fungus infection<\/strong>, not only bacteria and fungi are controlled but also <strong>the inflammatory process<\/strong> is favorably influenced by <strong>Ichthammol\u00ae<\/strong>.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>In <strong>veterinary medicine, Ichthammol\u00ae<\/strong> may be used locally on all <strong>food-producing mammals, including milk-producing ones<\/strong>, in accordance with legal regulations in Europe. Major indications are <strong>abscesses, boils, panaritium and phlegmones<\/strong>.<\/p>\n<p>Applications are also described, for example, for minor <strong>infected puncture or cutting wounds<\/strong>. At best, the infection is &#8220;drawn&#8221; outward through the softened skin barrier after application of <strong>Ichthammol\u00ae Ointment<\/strong>, with the aid of <strong>osmotic interface effects<\/strong> on the skin, or it dissolves. In this case, we speak of a <strong>drawing effect<\/strong>, which is attributed to the so-called <strong>drawing salves<\/strong>.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Please contact us for further information on the use of Ichthammol\u00ae.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_1\" href=\"\/en\/raw-materials-for-corporate-customers\/contact\/\"><span class=\"w-btn-label\">Contact<\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_c70c97eb en_overflow_hide height_large\" id=\"pharmacology\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mikroskop-1024x683.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mikroskop-1024x683.jpg 1024w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/09\/Mikroskop-300x200.jpg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" title=\"\"><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Pharmacology&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The use of <strong>Ichthammol\u00ae<\/strong> in the <strong>treatment of inflammatory skin disorders<\/strong> has been established worldwide for a long time. The <strong>anti-inflammatory, antibacterial and antifungal<\/strong> properties of <strong>Ichthammol\u00ae<\/strong> have been demonstrated in extensive in vitro studies. In addition, <strong>anti-pruritic, hyperemic and anti-seborrheic effects<\/strong> have also been reported for <strong>Ichthammol\u00ae<\/strong>. The well-known drawing effect is attributed to osmotic interface effects on the skin in conjunction with blood flow stimulating properties.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs accordion toggle_style_1 has_scrolling\" style=\"--sections-title-size:inherit;--sections-gap:0.5rem;\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"r904\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-r904\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Anti-inflammatory properties<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-r904\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3>Anti-inflammatory properties<\/h3>\n<p>As already known since 1882, <strong>Ichthammol\u00ae<\/strong> is <strong>therapeutically effective<\/strong> in treatment of <strong>inflammatory dermatoses<\/strong>. The mechanisms of action have been studied at the cellular level.<\/p>\n<p>By means of in <strong>vitro studies<\/strong> it was possible to demonstrate on cellular level that <strong>Ichthammol\u00ae<\/strong> is able to inhibit the activity of enzymes (lipoxygenase, cyclooxygenase) which are involved in degradation of arachidonic acid. The derivatives of arachidonic acid belong to the extremely potent cellular inflammation mediators. As has been demonstrated by various research groups, <strong>Ichthammol\u00ae<\/strong> inhibits the formation of LTB4 in a concentration-dependent manner. By inhibiting cyclooxygenase, <strong>Ichthammol\u00ae has an analgesic (pain-relieving)<\/strong> effect by reducing the formation of prostaglandins.<\/p>\n<p>In addition, <strong>Ichthammol\u00ae<\/strong> was found to have an influence on the <strong>biological effects of the inflammatory mediators<\/strong> themselves. Both an inhibition of cell migration, which is normally triggered by chemotactic factors such as LTB4, and an inhibition <strong>of the formation of reactive oxygen species<\/strong> and the <strong>release of calcium ions<\/strong> were observed.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"lac2\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-lac2\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Antimicrobial properties<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-lac2\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3>Antimicrobial properties<\/h3>\n<p><strong>Ichthammol\u00ae<\/strong> is effective in <strong>eliminating various strains of bacteria<\/strong>. Its efficacy was evaluated by determining the Minimum Inhibitory Concentration (MIC) in vitro. <strong>Ichthammol\u00ae<\/strong> is particularly effective against gram-positive species that play an important role in skin diseases caused by bacterial infestation (e.g. Staphylococcus aureus).<\/p>\n<p>Dermatophytes such as Microsporum gypseum and canis are very sensitive to the presence of <strong>Ichthammol\u00ae<\/strong>. The CO2 respiration of fungi is impeded even at very low concentrations of the active ingredient. <strong>Ichthammol\u00ae<\/strong> is able to stop the growth of various dermatophytes.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Please contact us for further information on the pharmacological profile of <strong>Ichthammol\u00ae<\/strong>.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_1\" href=\"\/en\/raw-materials-for-corporate-customers\/contact\/\"><span class=\"w-btn-label\">Contact<\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_5fb9c346 en_overflow_hide height_large\" id=\"toxicology\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Toxicology&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"w-separator size_medium\"><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Unlike production of tar, which takes place at temperatures well above 1000\u00b0C and thus favors the formation of polycyclic aromatic hydrocarbons (PAHs), the gentle production of <strong>Ichthammol\u00ae<\/strong> from <strong>dry distillation<\/strong> in Orbagnoux, France, to completion in Reith bei Seefeld, Tyrol, is associated with a particularly low PAH content, which contributes to the <strong>toxicological safety<\/strong> of the active ingredient.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Ichthammol\u00ae is not a tar<\/strong><br \/>\nThe <strong>production of shale oil from the biomass of the Orbagnoux limestone<\/strong> is aimed at pharmaceutical use and is carried out only for this purpose. The release of shale oil from the rock is already successful at <strong>temperatures starting from 300\u00b0C<\/strong>. The <strong>gently performed dry distillation procedure<\/strong> in connection with the purification of the shale oil by <strong>vacuum distillation<\/strong> and the subsequent <strong>sulfonation\/neutralization<\/strong> leads to the formation of surface active compounds. <strong>Benzo[a]pyrene<\/strong> as the lead substance of PAH is limited to a content of <strong>maximum 0.05\u00a0ppm<\/strong>.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The <strong>investigation<\/strong> of acute, subacute and chronic <strong>toxicity<\/strong>, local <strong>tolerability<\/strong> as well as teratogenic, mutagenic and carcinogenic potential demonstrated <strong>good tolerability<\/strong> of <strong>Ichthammol\u00ae<\/strong> both for <strong>short-term and long-term administration<\/strong>. There were no indications of teratogenic, mutagenic or carcinogenic properties.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs accordion toggle_style_1 has_scrolling remove_indents\" style=\"--sections-title-size:inherit;--sections-gap:0.5rem;\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"a094\"><button type=\"button\" class=\"w-tabs-section-header\" aria-controls=\"content-a094\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Read more<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-a094\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The <strong>safety and good tolerability<\/strong> of <strong>Ichthammol\u00ae<\/strong> are important prerequisites for its <strong>safe and broad use<\/strong> in <strong>veterinary medicine<\/strong>.<br \/>\nIn the framework of the procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (MRL procedure according to Regulation (EEC) 2377\/90), <strong>Ichthammol\u00ae<\/strong> was assigned to Annex II. Annex II includes those substances for which it is not considered necessary to establish maximum residue limits to protect consumers. This classification allows the <strong>unrestricted topical application of Ichthammol\u00ae<\/strong> to all food-producing mammals &#8211; including milk-producing ones.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Please contact us for further information on the toxicological profile of <strong>Ichthammol\u00ae<\/strong>.<\/p>\n<\/div><\/div><div class=\"w-separator size_custom\" style=\"height:0.5rem\"><\/div><div class=\"w-btn-wrapper align_none\"><a class=\"w-btn us-btn-style_5\" href=\"\/en\/raw-materials-for-corporate-customers\/contact\/\"><span class=\"w-btn-label\">Contact<\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_a9be633b en_overflow_hide height_large\" id=\"offers\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default reversed stacking_default\"><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Offers and further information&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><a href=\"https:\/\/www.ichthyol.de\/en\/raw-materials-for-corporate-customers\/contact\/\">Contact<\/a> us for a <strong>quotation for Ichthammol\u00ae<\/strong> in the quality and quantity you require. We usually deliver <strong>worldwide at short notice<\/strong> directly from our GMP warehouse in Hamburg.<\/p>\n<p>The goods are shipped to our international customers in <strong>UN-certified containers<\/strong> in quantities of <strong>5 kg, 50 kg and 200 kg<\/strong> with appropriate labeling (GDP-compliant if relevant). Close coordination with customers before, during and after order processing is ensured.<\/p>\n<p>Our team is at your disposal for <strong>regulatory and scientific questions<\/strong>. Our documentation is comprehensive and also covers regulatory topics in the target countries. <strong>Stability tests<\/strong> under consideration of climatic zones ensure a <strong>minimum shelf life of 6 years<\/strong> for <strong>Ichthammol\u00ae<\/strong>.<\/p>\n<p>If you have any questions regarding the <strong>availability of Ichthammol\u00ae<\/strong> in a specific distribution area, please do not hesitate to contact us. You can find <strong>our general terms and conditions<\/strong> <a href=\"\/wp-content\/uploads\/2022\/09\/General_Terms_and_Conditions_of_Delivery_and_Sales_-_ICHTHYOL_-_raw_materials.pdf\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Your Ichthyol\u00ae Team<\/p>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Phone: +49 40 50714 -108 \/ -180 \/ -360 \/ -367<br \/>\neMail <a href=\"mailto:rawmaterial@ichthyol.com\">rawmaterial@ichthyol.com<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-12 vc_col-lg-6 vc_col-md-6 vc_col-xs-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/12\/Ichthammol-fass-50kg-favorit_hochk-scaled-1-768x1024.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/12\/Ichthammol-fass-50kg-favorit_hochk-scaled-1-768x1024.jpg 768w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/12\/Ichthammol-fass-50kg-favorit_hochk-scaled-1-225x300.jpg 225w, https:\/\/www.ichthyol.de\/wp-content\/uploads\/2022\/12\/Ichthammol-fass-50kg-favorit_hochk-scaled-1.jpg 1920w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" title=\"\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"[vc_custom_heading text=\"Ichthammol\u00ae\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"]Ichthammol\u00ae, the ammonium salt of dark sulfonated shale oil, has been successfully used as an active ingredient of natural origin in the treatment of skin disorders for more than 100 years. The following pages will convince you of the documented quality and proven efficacy profile of this well-tolerated substance. 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